followers, investors and the public as a guidance through the past events and possible
outcomes of these e vents in the upcoming quarter(s). The goal of this Quarterly Report
is to inform about the activities and business achievements accomplished Hard to Treat
Diseases Inc. during the January 1 March 30, 2010 period. This report assembles and
summarizes all developments achieved during this time period.
Serbia and Mainland China and a cosmetics company in Canada
biological vaccines in China.
technologies they carry out clinical trials, secure registrations, and promote and market
products around the world.
neurological disorders of the central nervous system (CNS), namely Multiple Sclerosis
and Traumatic Brain Injury, and developing therapeutic treatments. The company's
primary focus involves the enhancement and modification of existing approved drugs
such as "Virazole" for the purpose of chemical repair of damage to the CNS (central
nervous system), MS (Multiple Sclerosis), SARS, Hepatitis C and HIV.
showcases anti-aging technology in a natural skin care line that repairs and rejuvenates.
2007 Shenzhen Mellow Hope Pharm.
No.6019 Shennan Blvd
1.3
new merger company, Collagenna, will market the skin care products, and Melem
Secrets will produce neutraceutical supplements. They commenced an expanded
distribution strategy, involving an agreement with a Swiss distribution company. Mellow
Hope developed several vaccines which received international certifications and
international customers. Slavica BioChem announced its plans to develop its own stem
cell projects.
children under 5 years were due to diseases that could have been prevented by routine
vaccination, representing 14% of total global mortality in children under 5 years of age.
Since 2000 momentum has built around immunization for preventable diseases, in part
due to a global health partnership between the WHO, UNICEF, World Bank and Bill &
Melinda Gates Foundation, known as the GAVI Alliance (
In eight years, a record number of vaccines became available worldwide, and 106 million
babies under the age of 1 were vaccinated in 2008, according to a joint report by the
World Health Organization, and United Nations. Immunization was partly responsible
for the first documented decline in annual deaths among children below 10 million, and
with helping to bring about a 74% drop in worldwide deaths from measles between
2000 and 2007. The global vaccine market tripled to $17 billion, and the boom has
spurred vaccine development aimed at AIDS, malaria, tuberculosis and dengue fever.
It is estimated that an additional investment of $1 billion USD would ensure availability
of the new and existing vaccines to all children in the world's 72 poorest countries
where preventable diseases take their deadliest toll.
In addition to aiding a good cause, the rising demand for immunization in the
developing world has profited global manufacturers, who now meet 86% of global
demand for traditional vaccines against diseases such as measles, whooping cough,
tetanus and diphtheria.
will benefit from the success of this industry. Mellow Hope's goal is to grow to become
one of the top vaccine distribution providers in the world and to restore global health.
large economic strain on patients' families and the health system.
to a broad range of symptoms, including physical and cognitive disabilities. MS affects
people between the ages of 20 to 50, people in the prime of their life.
suffer from Multiple Sclerosis (MS). With the high global population's growth rate
(anticipated to reach 7.6 billion by 2020), the prevalence and onset of MS in children
and adults is expected to increase exponentially.
Germany, Italy, UK, and Spain. These seven major market MS revenues increased 14.7%
to $4.6 billion in 2006 alone, and reached total global revenues of over $6 billion in
2008. Those revenues will exceed $9 billion (2015-2020).
injury that disrupts the normal function of the brain. The majority of TBI cases (60%)
result from Road Traffic Injuries (RTIs), followed by falls (20-30%) and violence (10%).
Americans receive treatment for TBI, with 230,000 hospitalizations. According to the US
Center for Disease Control and Prevention, every 15 seconds one American sustains a
significant traumatic brain injury, and about one third of injury related deaths in USA
death and disability by 2020.
the lost earnings of injured individuals and their caregivers, indicate national
expenditures of $56.3 billion USD annually.
neurological disorders outlined above.
customers continue to spend on skin care products, particularly anti-aging facial skin
products. Further, Collagenna's natural product niche means it is poised to benefit from
the largest growth in the sector.
Despite a minimal decline in 2009, the market research company NPD predicts return to
growth. Forecasts calculate a market value of $58.2 billion by 2012.
2009, with NPD's point of sale data estimating its worth at $1.2 billion. NPD's Women's
Skincare In-Depth Consumer Report, which surveyed over 6,000 consumers, revealed
that anti-aging is
important to them.
industry, with sales increasing by 20% a year. (2007) Consumers are increasingly
demanding of green products today, and in response, large cosmetic companies,
retailers, drugstores and pharmacies across North America and Western Europe are
incorporating natural and organic cosmetics into their product offerings.
February. Around that time, investors expressed concern about the lack of news for the
company. In the second half of the quarter, there were many news and filings with
updates about the exciting company developments.
company. Instead, Slavica Biochem decided to commence its own stem cell bank
project. Stem cells have potential therapeutical use for neurodegenerative disorders.
for HTDS' sale of MindUp Division, as a special onetime payment of kind. 40,000,000
shares of Hiru Corporation were issued from this agreement. The next day, the company
informed shareholders of a five-for-one forward split (5-1) of the Company's common
stock, adjusting the HTDS payout from 40 million shares to 200 million shares.
type medical company, engaged in a treatment for pre-term labor and induction of
labor. The results of the merger discussions are not yet determined.
micro-conglomerate merger, resulting in the acquisition of Collagenna Skin Care
Products Inc (Collagenna), a thriving micro cosmetics company. Collagenna Skin Care
Products Inc will take over the management of Melem's Secret and will look after all of
the aspects of this company including product development. Collagenna was acquired
on all cash basis therefore the existing share structure of HTDS remained undisturbed
and unchanged.
company believes that this occurrence stems from the stubborn naked short position
and an incorrect assumption that the company was diluting its float. There is also
speculation that this label occurred because of limited filings. Mid-month bashers were
responsible for degrading Mellow Hope's agreement with Chile, speculating that the
news was not sufficient evidence of the agreement. HTDS has taken legal action on this
matter. As with the planned distribution of the MindUp division to its shareholders, the
company is looking at other ways to shake the naked shorts and, more importantly,
return value to its shareholders. A reverse takeover is one option being explored by the
company with an unrelated entity engaged in a medical rejuvenative reconstruction, an
unrelated issuer in a medical industry, and a medical supply development company
creating a 4-way medical conglomerate. HTDS is actively working hard at removing their
company from the "skull and bones" status.
Slavica's profile. In early January, their research group, IBISS, participated in the Moscow
International Salon of Inventions and Innovation Technologies, representing the "delay
of Glial Scar Formation as a Prerequisite of Recovery after Central Nervous System
Injury."On February 5 and 6, two members of its scientific team, Dr. Sanja Pekovic, Chief
Project Scientist, Chief Strategy Officer and Dr. Ivana Gadjanski, participated in the
"Stem Cells and Neuroregeneration" Symposium, held in Haarlem, the Netherlands. The
main topic of the Symposium was the potential therapeutical use of neural stem cells for
neurodegenerative disorders
business. On February 18, subsidiary Mellow Hope exported its first shipment of the
H1N1 vaccine to Chile. The company values the price of the order at about $1 million
USD. On March 1, Mellow Hope announced that the company had a final evaluation
meeting with the Drug Controller General of India on Cerebroprotein Hydrolysate for
Injection. The company entered the final stage of product quality testing which will
result in the issue of a Registration Certificate for the medicine. The company believes
that, once approved, HTDS will be the only supplier of this product to India, and
estimates Nutriprotein market size to 2 to 3 million doses annually. Nutriprotein
medicine is a unique brain nutrient that helps the Central Nervous System in regulating
and improving nerve cell metabolism, promoting synapse generation, inducing nerve
cell differentiation and protecting nerve cells against damages by ischemia, neurotoxins,
etc. Mellow Hope also received a Registration Certificate for its MEVAC-Vari vaccine in
Guatemala. This is the first Final Approval for HTDS' Varicella vaccine in South America.
In general, doctors regard Varicella, commonly known as chickenpox, as a mild viral
illness. However, approx. 1 in 50 cases chickenpox associates with complications such as
pneumonia and encephalitis, and both diseases report high mortality rate. On March 15,
following 18 months of testing and negotiations, Chile's Ministry of Health approved
two of HTDS' penem injectables, Meropenem for Injection (MEINEN) and Imipenem for
Injection (IMINEN). HTDS received the registration certificate for these two medications
South American market.
they announced an exclusive distribution agreement with Alphaderm Body and Wellness
from Switzerland. On March 17 Collagenna received its first major order from its
distribution partner in Brazil. Over 600 products were ordered, with a total value of
approximately $36,000. At the end of the quarter, Melem Secrets distinguished their
brand's product offering neutraceutical supplements and natural health products. The
company will introduce a new Baobab supplement that originates from Africa and has
many health benefits such as its antioxidant value, its high source of calcium, iron,
potassium, magnesium and Vitamin C. Melem Secret plans to market other products
including Marine Collagen Capsules, Omega 3 gel capsules as well as the Skin Defense
Complex Caps.
https://www.leaddiscovery.co.uk/reports/1422/The_Global_Multiple_Sclerosis_Market_20
092024
https://reports.pharmalicensing.com/public/store/item/536-commercial-insight-
multiple-sclerosis-continued-growth-makes-the-ms-market-a-highly-attractive-
investment
http://www.slavicabiochem.com/multipleSclerosis.html
http://www.medicalnewstoday.com/articles/179837.php
http://www.pakjns.com/Previous/Archived/Jan-Mar-
09/Contents/docs/27_Perspective.pdf
Global Immunizations Hit Record but Miss Millions, David Morgan, Reuters, Oct. 21,
2010; http://www.reuters.com/article/idUSN20431309
Vaccine-preventable Diseases, World Health Organization;
http://www.who.int/immunization_monitoring/diseases/en/
http://www.researchandmarkets.com/reports/54470
http://www.organicmonitor.com
http://www.cosmeticsdesign.com/Products-Markets/Anti-aging-prestige-skincare-
market-set-to-return-to-growth
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affect," "believed," "estimate," "project" and similar words and phrases are intended to
identify such forward-looking statements. Hard to Treat Diseases Inc. cautions you that
any forward-looking information provided by or on behalf of Hard to Treat Diseases Inc.
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Hard to Treat Diseases Inc.'s actual results may differ materially from those anticipated
in such forward-looking statements as a result of various important factors, some of
which are beyond Hard to Treat Diseases Inc.'s control. In addition to those discussed in
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Treat Diseases Inc.'s management, including, but not limited to Hard to Treat Diseases
Inc.'s estimate of the sufficiency of its existing capital resources, Hard to Treat Diseases
Inc.'s ability to raise additional capital to fund future operations, Hard to Treat Diseases
Inc.'s ability to repay its existing indebtedness, the uncertainties involved in estimating
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Inc.'s capability to be awarded contracts. All such forward-looking statements are
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